Oral administration (during meals or on an empty stomach with liquid).
Daily doses vary within the range of 30-160 mg/kg of the body weight. Dosage frequency is 2-4 times/day.
Memory and intellectual disorders: 2.4-4.8 g / day, divided into 2-3 administrations.
In case of the chronic psycho-organic syndrome the drug is prescribed at a dose of 2.4-4.8 g/day during the first week, and then the patient is transferred to the maintenance dose of 1.2-2.4 g/day.
When treating consequences of an ischemic stroke Nootropil is prescribed at a dose of 4.8 g/day.
When treating coma and difficulties in perception in people with brain injury, the initial dose is 9-12 g/day, the maintenance dose is 2.4 g/day. The treatment should continue for at least 3 weeks.
When treating abstinence in case of chronic alcohol addiction the dose of the drug reaches 12 g/day during the manifestation of the alcohol withdrawal syndrome. The maintenance dose is 2.4 g/day.
When treating dizziness and related equilibrium disorders the dose is 2.4-4.8 g/day.
In case of cortical myoclonia, the treatment starts with a dose of 7.2 g/day, every 3-4 days the dose is increased by 4.8 g/day until the maximum dose of 24 g/day is reached. The treatment continues throughout the whole period of the disease. Every 6 months attempts should be made to reduce the dose or discontinue the drug gradually reducing the dose by 1.2 g/day every 2 days. In case of lack of efficacy or a slight therapeutic effect, the treatment is discontinued.
In case of sickle cell anemia, the daily preventive dose is 160 mg/kg of the body weight divided into 4 intakes. During the crisis – up to 300 mg/kg intravenous.
Treatment of dyslexia in children (as part of complex therapy): the recommended daily dosage for children from 8 years and adolescents – 3.2 g, divided into 2 administrations.
Special Groups of Patients
Kidney disorder: The dose should be adjusted depending on the amount of creatinine clearance (see the table below).
The creatinine clearance for men can be calculated based on the serum creatinine concentration, according to the following formula:
Creatinine clearance, ml/min = [(140 – age, years) × body weight, kg] / (72 × serum creatinine concentration, mg/dL)
The creatinine clearance for women can be calculated by multiplying the obtained value by a factor of 0.85.
||Creatinine clearance, ml/min
||2/3 of the usual dose in 2-3 intakes
||1/3 of the usual dose in 2 intakes
||1/6 of the usual dose in a single intake
The dose for elderly patients is adjusted in case of kidney failure. The monitoring of the functional state of the kidneys is necessary in case of the long-term therapy.
Liver disorder: Dose adjustment is not required for patients with the liver failure. For patients with both kidney and liver disorders, the dosing is prescribed according to the scheme (see ‘’Kidney disorder”).